TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS.
第一作者:
Simone,Kennard
第一单位:
Vascular Biology Center, Medical College of Georgia, Georgia Regents University, 1459 Laney Walker Blvd., Augusta, Georgia 30912, USA.
作者:
医学主题词
动物(Animals);结合部位(Binding Sites);牛(Cattle);细胞, 培养的(Cells, Cultured);内皮细胞(Endothelial Cells);酶抑制剂(Enzyme Inhibitors);细胞外信号调节MAP激酶类(Extracellular Signal-Regulated MAP Kinases);人类(Humans);小鼠(Mice);一氧化氮(Nitric Oxide);一氧化氮合酶Ⅲ型(Nitric Oxide Synthase Type III);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);大鼠(Rats);丝氨酸(Serine);种特异性(Species Specificity);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1016/j.vph.2016.04.003
PMID
27073025
发布时间
2018-11-13
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