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The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.

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第一作者： Baokun,He

第一单位： Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA.

作者： Baokun,He ^[1] ; Kazunari,Nohara ^[1] ; Noheon,Park ^[2] ; Yong-Sung,Park ^[1] ; Bobby,Guillory ^[3] ; Zhaoyang,Zhao ^[1] ; Jose M,Garcia ^[3] ; Nobuya,Koike ^[4] ; Cheng Chi,Lee ^[1] ; Joseph S,Takahashi ^[5] ; Seung-Hee,Yoo ^[1] ; Zheng,Chen ^[6]

作者单位： Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA. ^[1] Department of Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. ^[2] Division of Endocrinology, Diabetes and Metabolism, MCL, Center for Translational Research in Inflammatory Diseases, Michael E. DeBakey Veterans Affairs Medical Center, and Department of Medicine, and Molecular and Cell Biology, Dan L. Duncan Cancer Center, Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA. ^[3] Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. ^[4] Department of Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[5] Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA. Electronic address: zheng.chen.1@uth.tmc.edu. ^[6]

关键词 Nobiletin circadian clock clock amplitude-enhancing small molecule metabolic syndrome natural flavonoid retinoid acid receptor-related orphan receptors (RORs)