Group sequential designs with prospectively planned rules for subpopulation enrichment.

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第一作者： Michael,Rosenblum

第一单位： Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, U.S.A.

作者： Michael,Rosenblum ^[1] ; Brandon,Luber ^[2] ; Richard E,Thompson ^[1] ; Daniel,Hanley ^[2]

作者单位： Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, U.S.A. ^[1] Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A. ^[2]

关键词 adaptive enrichment design group sequential design optimal sample size

主题词人类(Humans);随机对照试验(主题)(Randomized Controlled Trials as Topic);研究设计(Research Design);样本大小(Sample Size);软件(Software);偏差(Uncertainty)

DOI 10.1002/sim.6957

PMID 27076411

发布时间 2018-12-02

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