Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.

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作者： Amir,Bashiri ^[1] ; Dinushan,Nesan ^[2] ; Ghazaleh,Tavallaee ^[2] ; Ian,Sue-Chue-Lam ^[2] ; Kevin,Chien ^[2] ; Graham F,Maguire ^[2] ; Mark,Naples ^[3] ; Jing,Zhang ^[3] ; Lilia,Magomedova ^[4] ; Khosrow,Adeli ^[3] ; Carolyn L,Cummins ^[4] ; Dominic S,Ng ^[5]

作者单位： Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael's Hospital, Toronto, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada. ^[1] Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael's Hospital, Toronto, Canada. ^[2] Molecular Structure and Function Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. ^[3] Faculty of Pharmacy, University of Toronto, Toronto, Canada. ^[4] Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael's Hospital, Toronto, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. Electronic address: ngd@smh.ca. ^[5]

关键词 Cholesterol crystal ER cholesterol ER stress Inflammasome LCAT knockout mice NASH