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Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

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第一作者： Vernon,Seow

第一单位： Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

作者： Vernon,Seow ^[1] ; Junxian,Lim ^[2] ; Adam J,Cotterell ^[1] ; Mei-Kwan,Yau ^[2] ; Weijun,Xu ^[2] ; Rink-Jan,Lohman ^[2] ; W Mei,Kok ^[2] ; Martin J,Stoermer ^[1] ; Matthew J,Sweet ^[3] ; Robert C,Reid ^[2] ; Jacky Y,Suen ^[2] ; David P,Fairlie ^[2]

作者单位： Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. ^[1] Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.;Centre for Inflammation and Disease Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.;ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. ^[2] Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.;Centre for Inflammation and Disease Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.;ARC Centre of Excellence in Advanced Molecular Imaging, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia. ^[3]