Normalizing the environment recapitulates adult human immune traits in laboratory mice.-论文-万方医学网

作者： Lalit K,Beura ^[1] ; Sara E,Hamilton ^[2] ; Kevin,Bi ^[3] ; Jason M,Schenkel ^[1] ; Oludare A,Odumade ^[2] ; Kerry A,Casey ^[1] ; Emily A,Thompson ^[1] ; Kathryn A,Fraser ^[1] ; Pamela C,Rosato ^[1] ; Ali,Filali-Mouhim ^[4] ; Rafick P,Sekaly ^[4] ; Marc K,Jenkins ^[1] ; Vaiva,Vezys ^[1] ; W Nicholas,Haining ^[3] ; Stephen C,Jameson ^[2] ; David,Masopust ^[1]

作者单位： Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota 55414, USA. ^[1] Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55414, USA. ^[2] Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Pediatric Hematology and Oncology, Children's Hospital, Boston, Massachusetts 02115, USA. ^[3] Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. ^[4]

主题词成年人(Adult);畜牧业(Animal Husbandry);动物(Animals);动物, 实验(Animals, Laboratory);动物, 野生(Animals, Wild);细胞分化(Cell Differentiation);环境(Environment);环境暴露(Environmental Exposure);女(雌)性(Female);人类(Humans);免疫系统(Immune System);免疫(Immunity);免疫, 先天(Immunity, Innate);免疫记忆(Immunologic Memory);婴儿, 新生(Infant, Newborn);男(雄)性(Male);小鼠(Mice);模型, 动物(Models, Animal);表型(Phenotype);无特异性病原体有机物(Specific Pathogen-Free Organisms);T淋巴细胞(T-Lymphocytes);病毒性疾病(Virus Diseases)

DOI 10.1038/nature17655

PMID 27096360

发布时间 2024-09-07

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Normalizing the environment recapitulates adult human immune traits in laboratory mice.

Nature

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Normalizing the environment recapitulates adult human immune traits in laboratory mice.

Nature

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Nature

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