Beware of your Cre-Ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory.

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第一作者： J M,Reichel

第一单位： Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804, Munich, Germany.;Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10461, Bronx, New York.

作者： J M,Reichel ^[1] ; B T,Bedenk ^[2] ; N C,Gassen ^[3] ; K,Hafner ^[3] ; S A,Bura ^[4] ; S,Almeida-Correa ^[4] ; A,Genewsky ^[4] ; N,Dedic ^[4] ; F,Giesert ^[5] ; A,Agarwal ^[6] ; K-A,Nave ^[7] ; T,Rein ^[3] ; M,Czisch ^[2] ; J M,Deussing ^[4] ; C T,Wotjak ^[8]

作者单位： Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804, Munich, Germany.;Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10461, Bronx, New York. ^[1] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804, Munich, Germany.;Core Unit Neuroimaging, Max Planck Institute of Psychiatry, 80804, Munich, Germany. ^[2] Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany. ^[3] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804, Munich, Germany. ^[4] Institute of Developmental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, Neuherberg, D-85764, Germany. ^[5] The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland. ^[6] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, 37075, Germany. ^[7] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804, Munich, Germany. wotjak@mpipsykl.mpg.de. ^[8]

关键词 cognition hippocampus memory impairment neurodegeneration neurotoxicity transgenic volume loss