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The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable.

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第一作者： Jesse,Mez

第一单位： Alzheimer's Disease Center, Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

作者： Jesse,Mez ^[1] ; Shubhabrata,Mukherjee ^[2] ; Timothy,Thornton ^[3] ; David W,Fardo ^[4] ; Emily,Trittschuh ^[5] ; Sheila,Sutti ^[6] ; Richard,Sherva ^[7] ; John S,Kauwe ^[8] ; Adam C,Naj ^[9] ; Gary W,Beecham ^[10] ; Alden,Gross ^[11] ; Andrew J,Saykin ^[12] ; Robert C,Green ^[6] ; Paul K,Crane ^[13] ; Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) ; Alzheimer's Disease Neuroimaging Initiative (ADNI1) ; Alzheimer's Disease Genetics Consortium (ADGC)

作者单位： Alzheimer's Disease Center, Department of Neurology, Boston University School of Medicine, Boston, MA, USA. ^[1] Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. ^[2] Department of Biostatistics, University of Washington, Seattle, WA, USA. ^[3] Department of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA. ^[4] Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. ^[5] G2P Program, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ^[6] Biomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. ^[7] Department of Biology, Brigham Young University, Provo, UT, USA. ^[8] Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[9] Miller School of Medicine, Hussman Institute for Human Genomics and Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, FL, USA. ^[10] Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. ^[11] IU Health Neuroscience Center, Department of Radiology, Indiana University, Indianapolis, IN, USA. ^[12] Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: pcrane@uw.edu. ^[13]

关键词 Atypical Alzheimer's disease Dysexecutive Alzheimer's disease Executive function Genetics Heritability Memory