首页> Bioorganic & medicinal chemistry> Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

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第一作者： Taisuke,Katoh

第一单位： Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: taisuke.katoh@takeda.com.

作者： Taisuke,Katoh ^[1] ; Takafumi,Takai ^[2] ; Takafumi,Yukawa ^[2] ; Tetsuya,Tsukamoto ^[2] ; Etsurou,Watanabe ^[2] ; Hideyuki,Mototani ^[2] ; Takeo,Arita ^[2] ; Hiroki,Hayashi ^[2] ; Hideyuki,Nakagawa ^[2] ; Michael G,Klein ^[3] ; Hua,Zou ^[3] ; Bi-Ching,Sang ^[3] ; Gyorgy,Snell ^[3] ; Yoshihisa,Nakada ^[2]

作者单位： Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: taisuke.katoh@takeda.com. ^[1] Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. ^[2] Takeda California, 10410 Science Center Drive, San Diego, CA 92121, USA. ^[3]

关键词 1,7-Disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones Inhibition of IL-2 production PKCθ inhibitors