换一批A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells.
第一作者：
D Sharma,Das
第一单位：
LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
作者：
医学主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);吖丁啶类(Azetidines);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物协同作用(Drug Synergism);表观基因组学(Epigenomics);人类(Humans);小鼠(Mice);多发性骨髓瘤(Multiple Myeloma);硝基化合物(Nitro Compounds);沙立度胺(Thalidomide);泛素硫酯酶(Ubiquitin Thiolesterase)
DOI
10.1038/leu.2016.96
PMID
27118403
发布时间
2022-03-31
基金项目
P01 CA078378/CA/NCI NIH HHS/United States
P50 CA100707/CA/NCI NIH HHS/United States
R01 CA050947/CA/NCI NIH HHS/United States
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Leukemia
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