Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects.

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第一作者： Lu,Gan

第一单位： Novartis Institutes for BioMedical Research, Cambridge, MA, USA.

作者： Lu,Gan ^[1] ; Xuemin,Jiang ^[2] ; Anisha,Mendonza ^[1] ; Therese,Swan ^[1] ; Christine,Reynolds ^[2] ; Joanne,Nguyen ^[2] ; Parasar,Pal ^[3] ; Srikanth,Neelakantham ^[3] ; Marion,Dahlke ^[4] ; Thomas,Langenickel ^[4] ; Iris,Rajman ^[4] ; Mizuki,Akahori ^[5] ; Wei,Zhou ^[2] ; Sam,Rebello ^[2] ; Gangadhar,Sunkara ^[2]

作者单位： Novartis Institutes for BioMedical Research, Cambridge, MA, USA. ^[1] Novartis Institutes for BioMedical Research, East Hanover, NJ, USA. ^[2] Novartis Healthcare Pvt Ltd, Hyderabad, Andhra Pradesh, India. ^[3] Novartis Institutes for BioMedical Research, Basel, Switzerland. ^[4] Novartis Pharma K.K, Tokyo, Japan. ^[5]

关键词 Angiotensin receptor neprilysin inhibitor Combination oral contraceptive Drug–drug interaction LCZ696 Metformin Omeprazole

主题词青少年(Adolescent);成年人(Adult);血管紧张素受体拮抗剂(Angiotensin Receptor Antagonists);曲线下面积(Area Under Curve);联苯化合物(Biphenyl Compounds);复方合剂(Drug Combinations);药物相互作用(Drug Interactions);炔雌醇(Ethinyl Estradiol);女(雌)性(Female);人类(Humans);左炔诺孕酮(Levonorgestrel);男(雄)性(Male);二甲双胍(Metformin);中年人(Middle Aged);奥美拉唑(Omeprazole);四唑类(Tetrazoles);青年人(Young Adult)

DOI 10.1002/cpdd.181

PMID 27119576

发布时间 2021-12-04

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Clinical pharmacology in drug development

2016年5卷1期

27-39页

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Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects.

Clinical pharmacology in drug development

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Clinical pharmacology in drug development

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Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects.

Clinical pharmacology in drug development

相似文献

Clinical pharmacology in drug development

相关期刊

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