Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

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作者： Talya L,Dayton ^[1] ; Vasilena,Gocheva ^[1] ; Kathryn M,Miller ^[1] ; William J,Israelsen ^[2] ; Arjun,Bhutkar ^[1] ; Clary B,Clish ^[3] ; Shawn M,Davidson ^[1] ; Alba,Luengo ^[1] ; Roderick T,Bronson ^[4] ; Tyler,Jacks ^[5] ; Matthew G,Vander Heiden ^[6]

作者单位： David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; ^[1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; ^[2] Metabolite Profiling Platform, Broad Institute, Cambridge, Massachusetts 02142, USA; ^[3] Department of Pathology, Tufts University School of Medicine and Veterinary Medicine, North Grafton, Massachusetts 01536, USA; ^[4] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; ^[5] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. ^[6]

关键词 HCC PKM2 metabolism