Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.-论文-万方医学网

作者： Kimihiko,Banno ^[1] ; Sayaka,Omori ^[2] ; Katsuya,Hirata ^[1] ; Nobutoshi,Nawa ^[1] ; Natsuki,Nakagawa ^[1] ; Ken,Nishimura ^[3] ; Manami,Ohtaka ^[4] ; Mahito,Nakanishi ^[4] ; Tetsushi,Sakuma ^[5] ; Takashi,Yamamoto ^[5] ; Tsutomu,Toki ^[6] ; Etsuro,Ito ^[6] ; Toshiyuki,Yamamoto ^[7] ; Chikara,Kokubu ^[8] ; Junji,Takeda ^[8] ; Hidetoshi,Taniguchi ^[1] ; Hitomi,Arahori ^[1] ; Kazuko,Wada ^[1] ; Yasuji,Kitabatake ^[9] ; Keiichi,Ozono ^[1]

作者单位： Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan. ^[1] Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan; Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-0083, Japan. ^[2] Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. ^[3] Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562, Japan. ^[4] Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526, Japan. ^[5] Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan. ^[6] Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666, Japan. ^[7] Department of Genome Biology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan. ^[8] Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan. Electronic address: ykitaba@ped.med.osaka-u.ac.jp. ^[9]

主题词碱基配对(Base Pairing);碱基序列(Base Sequence);细胞分化(Cell Differentiation);细胞谱系(Cell Lineage);染色体, 人, 21对(Chromosomes, Human, Pair 21);唐氏综合征(Down Syndrome);上位性, 遗传(Epistasis, Genetic);红细胞生成(Erythropoiesis);GATA1转录因子(GATA1 Transcription Factor);基因敲除技术(Gene Knockout Techniques);血细胞生成(Hematopoiesis);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);巨核细胞(Megakaryocytes);模型, 生物学(Models, Biological);突变(Mutation);RNA编辑(RNA Editing);序列缺失(Sequence Deletion);转录因子(Transcription Factors);增量调节(Up-Regulation)

DOI 10.1016/j.celrep.2016.04.031

PMID 27134169

发布时间 2022-03-16

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Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.

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Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.

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