Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.

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作者： Catherine C,Bell ^[1] ; Delilah F G,Hendriks ^[1] ; Sabrina M L,Moro ^[1] ; Ewa,Ellis ^[2] ; Joanne,Walsh ^[3] ; Anna,Renblom ^[1] ; Lisa,Fredriksson Puigvert ^[1] ; Anita C A,Dankers ^[4] ; Frank,Jacobs ^[4] ; Jan,Snoeys ^[4] ; Rowena L,Sison-Young ^[3] ; Rosalind E,Jenkins ^[3] ; Åsa,Nordling ^[1] ; Souren,Mkrtchian ^[1] ; B Kevin,Park ^[3] ; Neil R,Kitteringham ^[3] ; Christopher E P,Goldring ^[3] ; Volker M,Lauschke ^[1] ; Magnus,Ingelman-Sundberg ^[1]

作者单位： Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden. ^[1] Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden. ^[2] MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Sherrington Buildings, Ashton Street, University of Liverpool, UK. ^[3] Janssen Pharmaceutical Companies of Johnson &Johnson, Department of Pharmacokinetics, Dynamics and Metabolism, Beerse, Belgium. ^[4]

主题词阿糖呋喃脲嘧啶(Arabinofuranosyluracil);细胞, 培养的(Cells, Cultured);肝细胞(Hepatocytes);人类(Humans);模型, 生物学(Models, Biological);蛋白质组(Proteome);球形体, 细胞(Spheroids, Cellular)

DOI 10.1038/srep25187

PMID 27143246

发布时间 2018-11-13

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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.

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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.

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