首页> Biomaterials> Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.

Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy.

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第一作者： Ziyan,Fang

第一单位： Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 58th Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, PR China; Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, 510370, PR China.

作者： Ziyan,Fang ^[1] ; Shuda,Chen ^[2] ; Jiaming,Qin ^[3] ; Bao,Chen ^[4] ; Guanzhong,Ni ^[3] ; Ziyi,Chen ^[3] ; Jueqian,Zhou ^[3] ; Ze,Li ^[2] ; Yuping,Ning ^[5] ; Chuanbin,Wu ^[6] ; Liemin,Zhou ^[7]

作者单位： Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 58th Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, PR China; Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, 510370, PR China. ^[1] Department of Neurology, Guangzhou First People's Hospital, 1st Panfu Road, Guangzhou, Guangdong, 510180, PR China. ^[2] Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 58th Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, PR China. ^[3] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, PR China. ^[4] Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital, Guangzhou, Guangdong, 510370, PR China. ^[5] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, PR China. Electronic address: chuanbinwu@126.com. ^[6] Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 58th Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, PR China. Electronic address: lmzhou56@163.com. ^[7]

关键词 Drug resistance Microdialysis Nanoparticles P-glycoprotein Phenytoin Tariquidar