Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance.

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作者： Kouichi,Shiraishi ^[1] ; Kumi,Kawano ^[2] ; Yoshie,Maitani ^[2] ; Taiki,Aoshi ^[3] ; Ken J,Ishii ^[4] ; Yusuke,Sanada ^[5] ; Shinichi,Mochizuki ^[5] ; Kazuo,Sakurai ^[5] ; Masayuki,Yokoyama ^[6]

作者单位： Medical Engineering Laboratory, Research Center for Medical Sciences, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan. ^[1] The Institute of Medicinal Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan. ^[2] Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation (NIBIO), 7-6-8 Asagi Saito, Ibaraki-City, Osaka 567-0085, Japan; Laboratory of Vaccine Science, World Premier International Immunology Frontier Research Center (IFREC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Vaccine Dynamics Project, BIKEN Innovative Vaccine Research Alliance Laboratories, the Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. ^[3] Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation (NIBIO), 7-6-8 Asagi Saito, Ibaraki-City, Osaka 567-0085, Japan; Laboratory of Vaccine Science, World Premier International Immunology Frontier Research Center (IFREC), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. ^[4] The Department of Chemistry and Biochemistry, the University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan. ^[5] Medical Engineering Laboratory, Research Center for Medical Sciences, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan. Electronic address: masajun2093ryo@jikei.ac.jp. ^[6]

关键词 Accelerated blood clearance (ABC) phenomenon Anti-PEG IgM antibody Hydrophobicity of conjugates PEG-liposomes Polymeric micelles