Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

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作者： Michael J,Van Kanegan ^[1] ; Denise E,Dunn ^[1] ; Linda S,Kaltenbach ^[1] ; Bijal,Shah ^[1] ; Dong Ning,He ^[1] ; Daniel D,McCoy ^[1] ; Peiying,Yang ^[2] ; Jiangnan,Peng ^[3] ; Li,Shen ^[4] ; Lin,Du ^[5] ; Robert H,Cichewicz ^[5] ; Robert A,Newman ^[6] ; Donald C,Lo ^[1]

作者单位： Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, US. ^[1] Department of Palliative Care, Rehabilitation and Integrative Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, US. ^[2] Department of Chemistry and Biochemistry, University of North Carolina at Wilmington, NC 28403, US. ^[3] Department of Pharmacy, Medical College of Yangzhou University, Yangzhou, China. ^[4] Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, Natural Products Discovery Group, and Institute for Natural Products Applications and Research Technologies, University of Oklahoma, Norman, Oklahoma 73019, US. ^[5] Department of Experimental Therapeutics, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, US. ^[6]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);脑(Brain);化学分馏法(Chemical Fractionation);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);葡萄糖(Glucose);人类(Humans);男(雄)性(Male);夹竹桃属(Nerium);神经变性疾病(Neurodegenerative Diseases);神经保护药(Neuroprotective Agents);齐墩果酸(Oleanolic Acid);器官培养技术(Organ Culture Techniques);氧(Oxygen);植物提取物(Plant Extracts);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);卒中(Stroke)

DOI 10.1038/srep25626

PMID 27172999

发布时间 2018-11-13

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Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

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Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.

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