Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation.

导出 OA

翻译打印收藏纠错

作者： Valentina,Proserpio ^[1] ; Andrea,Piccolo ^[2] ; Liora,Haim-Vilmovsky ^[3] ; Gozde,Kar ^[1] ; Tapio,Lönnberg ^[2] ; Valentine,Svensson ^[1] ; Jhuma,Pramanik ^[1] ; Kedar Nath,Natarajan ^[2] ; Weichao,Zhai ^[1] ; Xiuwei,Zhang ^[1] ; Giacomo,Donati ^[2] ; Melis,Kayikci ^[1] ; Jurij,Kotar ^[2] ; Andrew N J,McKenzie ^[4] ; Ruddy,Montandon ^[1] ; Oliver,Billker ^[5] ; Steven,Woodhouse ^[6] ; Pietro,Cicuta ^[4] ; Mario,Nicodemi ^[6] ; Sarah A,Teichmann ^[2]

作者单位： EMBL, European Bioinformatics Institute (EBI), Hinxton, CB10 1SD, UK. ^[1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. ^[2] Department of Physics, University of Naples Federico II, CNR-Spin, Istituto Nazionale di Fisica Nucleare (INFN), Napoli, Italy. ^[3] Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge, CB3 0HE, UK. ^[4] Centre for Stem Cells and Regenerative Medicine, Kings College London, London, SE1 9RT, UK. ^[5] MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. ^[6] Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK. ^[7] Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. ^[8] Department of Physics, University of Naples Federico II, CNR-Spin, Istituto Nazionale di Fisica Nucleare (INFN), Napoli, Italy. mario.nicodemi@na.infn.it. ^[9] EMBL, European Bioinformatics Institute (EBI), Hinxton, CB10 1SD, UK. st9@sanger.ac.uk. ^[10] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. st9@sanger.ac.uk. ^[11]

关键词 Adaptive immunity CD4+ T cells Cell cycle Differentiation Live imaging Single-cell RNA-seq