换一批Recombinant targeted toxin based on HER2-specific DARPin possesses a strong selective cytotoxic effect in vitro and a potent antitumor activity in vivo.
第一作者：
Evgeniya,Sokolova
第一单位：
M.M. Shemyakin and Y.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997, Russia; Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., Nizhny Novgorod 603950, Russia.
作者：
医学主题词
ADP核糖转移酶类(ADP Ribose Transferases);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细菌毒素类(Bacterial Toxins);CHO细胞(CHO Cells);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);仓鼠属(Cricetulus);外毒素类(Exotoxins);女(雌)性(Female);人类(Humans);免疫毒素类(Immunotoxins);乳房肿瘤, 实验性(Mammary Neoplasms, Experimental);小鼠, 裸(Mice, Nude);重组融合蛋白质类(Recombinant Fusion Proteins);肿瘤负荷(Tumor Burden);毒力因子类(Virulence Factors)
DOI
10.1016/j.jconrel.2016.05.020
PMID
27178808
发布时间
2023-12-13
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