Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction.

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作者： Hayato,Fukuda ^[1] ; Saki,Ito ^[1] ; Kenji,Watari ^[2] ; Chihiro,Mogi ^[3] ; Mitsuhiro,Arisawa ^[1] ; Fumikazu,Okajima ^[3] ; Hitoshi,Kurose ^[2] ; Satoshi,Shuto ^[4]

作者单位： Faculty of Pharmaceutical Science, Hokkaido University , Kita-12, Nishi-6, Kita-Ku, Sapporo 060-0812, Japan. ^[1] Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ^[2] Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University , 3-39-15 Showa-machi, Maebashi 371-8512, Japan. ^[3] Faculty of Pharmaceutical Science, Hokkaido University, Kita-12, Nishi-6, Kita-Ku, Sapporo 060-0812, Japan; Center for Research and Education on Drug Discovery, Hokkaido University, Kita-12, Nishi-6, Kita-Ku, Sapporo 060-0812, Japan. ^[4]

关键词 GPR4 dibenzazepine derivatives myocardial infarction pH-sensing GPCR

DOI 10.1021/acsmedchemlett.6b00014

PMID 27190599

发布时间 2020-09-30

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