Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations.-论文-万方医学网

作者： Michal,Yalon ^[1] ; Liron,Tuval-Kochen ^[2] ; David,Castel ^[2] ; Itai,Moshe ^[3] ; Inbal,Mazal ^[4] ; Osher,Cohen ^[1] ; Camila,Avivi ^[2] ; Kineret,Rosenblatt ^[5] ; Sarit,Aviel-Ronen ^[6] ; Ginette,Schiby ^[6] ; Joachim,Yahalom ^[6] ; Ninette,Amariglio ^[6] ; Raphael,Pfeffer ^[7] ; Yaacov,Lawrence ^[2] ; Amos,Toren ^[2] ; Gideon,Rechavi ^[2] ; Shoshana,Paglin ^[1]

作者单位： Department of Pediatric Hematology-Oncology, Safra Children's Hospital, Sheba Medical Center, Ramat Gan 52621, Israel. ^[1] Cancer Research Center, Sheba Medical Center, Ramat-Gan 52621, Israel. ^[2] Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. ^[3] Neufeld Cardiac Research Institute, Sheba Medical Center, Ramat Gan 52621, Israel. ^[4] Department of Surgery, Sheba Medical Center, Ramat-Gan 52621, Israel. ^[5] Department of Pathology, Sheba Medical Center, Ramat-Gan 52621, Israel. ^[6] Department of Radiation Oncology, Memorial Sloan Kettering, New York 10021, United States of America. ^[7]

主题词动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);BRCA1蛋白质(BRCA1 Protein);苯咪唑类(Benzimidazoles);载体蛋白质类(Carrier Proteins);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);真核细胞起始因子2(Eukaryotic Initiation Factor-2);女(雌)性(Female);成纤维细胞(Fibroblasts);人类(Humans);羟肟酸类(Hydroxamic Acids);小鼠(Mice);小鼠, 裸(Mice, Nude);肿瘤移植(Neoplasm Transplantation);磷酰化(Phosphorylation);质粒(Plasmids);Rad51重组酶(Rad51 Recombinase);重组, 遗传(Recombination, Genetic);硫鸟嘌呤(Thioguanine);体重减轻(Weight Loss)

DOI 10.1371/journal.pone.0155711

PMID 27196668

发布时间 2022-03-17

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Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations.

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Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations.

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