IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer.
第一作者:
Mauricio S,Caetano
第一单位:
Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
作者:
医学主题词
腺癌(Adenocarcinoma);动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞增殖(Cell Proliferation);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);人类(Humans);免疫酶技术(Immunoenzyme Techniques);白细胞介素6(Interleukin-6);肺肿瘤(Lung Neoplasms);小鼠(Mice);突变(Mutation);NF-κB(NF-kappa B);肿瘤分期(Neoplasm Staging);预后(Prognosis);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);RNA, 信使(RNA, Messenger);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction);存活率(Survival Rate);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤微环境(Tumor Microenvironment)
DOI
10.1158/0008-5472.CAN-15-2840
PMID
27197187
发布时间
2022-03-10
- 浏览3
Cancer research
3189-99页
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