Exploring the impact of sample flowrate on in vitro measurements of metered dose inhaler performance.

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作者： D A,Lewis ^[1] ; H,O'Shea ^[2] ; T K,Church ^[2] ; G,Brambilla ^[2] ; D,Traini ^[3] ; P M,Young ^[3]

作者单位： Chiesi Ltd., Bath Rd. Ind. Est., Chippenham, Wiltshire SN14 0AB, UK. Electronic address: d.lewis@chiesi.com. ^[1] Chiesi Ltd., Bath Rd. Ind. Est., Chippenham, Wiltshire SN14 0AB, UK. ^[2] Respiratory Technology, Woolcock Institute of Medical Research, The University of Sydney, 2006, Australia; Discipline of Pharmacology, Sydney Medical School, The University of Sydney, 2006, Australia. ^[3]

关键词 Aerodynamic particle size distribution Alberta idealized throat Cascade impactor Fine particle dose Metered dose inhalers Testing conditions

主题词投药, 吸入(Administration, Inhalation);药物调剂(Drug Compounding);设备设计(Equipment Design);人类(Humans);定量雾化吸入器(Metered Dose Inhalers);粒子大小(Particle Size);流变学(Rheology)

DOI 10.1016/j.ijpharm.2016.05.025

PMID 27210737

发布时间 2017-05-17

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