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首页> Neurotoxicology> Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity.

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity.

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作者： Anna,Bal-Price ^[1] ; Pamela J,Lein ^[2] ; Kimberly P,Keil ^[2] ; Sunjay,Sethi ^[2] ; Timothy,Shafer ^[3] ; Marta,Barenys ^[4] ; Ellen,Fritsche ^[4] ; Magdalini,Sachana ^[5] ; M E Bette,Meek ^[6]

作者单位： European Commission Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Italy. Electronic address: anna.price@ec.europa.eu. ^[1] Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA. ^[2] Integrated Systems Toxicology Division, Office of Research and Development, U.S. Environmental Protection Agency, RTP, USA. ^[3] IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. ^[4] European Commission Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Italy. ^[5] McLaughlin Centre for Risk Science, University of Ottawa, Ottawa, Canada. ^[6]

关键词 Adverse outcome pathways Mode of action Neurotoxicity Risk assessment

主题词动物(Animals);人类(Humans);神经系统(Nervous System);神经中毒综合征(Neurotoxicity Syndromes);神经毒素类(Neurotoxins);危险性评估(Risk Assessment);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.neuro.2016.05.010

PMID 27212452

发布时间 2018-11-13

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