Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene.

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第一作者： Yuting,Chen

第一单位： Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.

作者： Yuting,Chen ^[1] ; Wenqing,Lu ^[1] ; Na,Gao ^[1] ; Yi,Long ^[1] ; Yanjiao,Shao ^[1] ; Meizhen,Liu ^[1] ; Huaqing,Chen ^[1] ; Shixin,Ye ^[2] ; Xueyun,Ma ^[1] ; Mingyao,Liu ^[3] ; Dali,Li ^[4]

作者单位： Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. ^[1] Ecole Normale Supérieure, Institut de Biologie de l' Ecole Normale Supérieure, Institut National de la Santé et de la Recherche Médicale U1024, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8197, Paris, F-75005, France. ^[2] Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. myliu@bio.ecnu.edu.cn.;Institute of Biosciences and Technology, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, Houston, Texas, 77030, USA. myliu@bio.ecnu.edu.cn. ^[3] Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. dlli@bio.ecnu.edu.cn. ^[4]

关键词 Lepr TALENs germ-line transmission knockout rat

主题词等位基因(Alleles);动物(Animals);碱基序列(Base Sequence);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);基因敲除技术(Gene Knockout Techniques);生殖细胞系突变(Germ-Line Mutation);葡糖耐量试验(Glucose Tolerance Test);肥胖症(Obesity);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 瘦素(Receptors, Leptin)

DOI 10.1007/s11427-016-5049-y

PMID 27225180

发布时间 2022-04-08

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Science China. Life sciences

2017年60卷2期

152-157页

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Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene.

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Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene.

Science China. Life sciences

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