首页> International journal of cancer> Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.

Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.

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第一作者： Carolina,Bonilla

第一单位： School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.;MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.

作者： Carolina,Bonilla ^[1] ; Sarah J,Lewis ^[1] ; Mari-Anne,Rowlands ^[2] ; Tom R,Gaunt ^[1] ; George,Davey Smith ^[1] ; David,Gunnell ^[2] ; Tom,Palmer ^[3] ; Jenny L,Donovan ^[2] ; Freddie C,Hamdy ^[4] ; David E,Neal ^[5] ; Rosalind,Eeles ^[6] ; Doug,Easton ^[7] ; Zsofia,Kote-Jarai ^[8] ; Ali Amin,Al Olama ^[7] ; Sara,Benlloch ^[7] ; Kenneth,Muir ^[9] ; Graham G,Giles ^[10] ; Fredrik,Wiklund ^[11] ; Henrik,Grönberg ^[11] ; Christopher A,Haiman ^[12] ; Johanna,Schleutker ^[13] ; Børge G,Nordestgaard ^[14] ; Ruth C,Travis ^[15] ; Nora,Pashayan ^[16] ; Kay-Tee,Khaw ^[17] ; Janet L,Stanford ^[18] ; William J,Blot ^[19] ; Stephen,Thibodeau ^[20] ; Christiane,Maier ^[21] ; Adam S,Kibel ^[22] ; Cezary,Cybulski ^[23] ; Lisa,Cannon-Albright ^[24] ; Hermann,Brenner ^[25] ; Jong,Park ^[26] ; Radka,Kaneva ^[27] ; Jyotsna,Batra ^[28] ; Manuel R,Teixeira ^[29] ; Hardev,Pandha ^[30] ; PRACTICAL consortium ^[31] ; Mark,Lathrop ^[32] ; Richard M,Martin ^[33] ; Jeff M P,Holly

作者单位： School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.;MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. ^[1] School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. ^[2] Department of Mathematics and Statistics, Lancaster University, Lancaster, United Kingdom. ^[3] Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom. ^[4] Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom.;Surgical Oncology (Uro-Oncology: S4), University of Cambridge, Box 279, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom. ^[5] The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom.;Royal Marsden NHS Foundation Trust, Fulham and Sutton, London and Surrey, United Kingdom. ^[6] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom. ^[7] The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom. ^[8] University of Warwick, Coventry, United Kingdom.;Institute of Population Health, University of Manchester, Manchester, M13 9PL, United Kingdom. ^[9] The Cancer Council Victoria, 615 St. Kilda Road, Melbourne, Victoria, 3004, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, the University of Melbourne, Victoria, 3010, Australia. ^[10] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. ^[11] Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California. ^[12] Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.;Institute of Biomedical Technology/BioMediTech, University of Tampere and FimLab Laboratories, Tampere, Finland. ^[13] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, DK, 2730, Denmark. ^[14] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. ^[15] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.;Department of Applied Health Research, University College London, 1-19 Torrington Place, London, WC1E 7HB, United Kingdom. ^[16] Forvie Site, Cambridge Institute of Public Health, University of Cambridge, Robinson Way, Cambridge, CB2 0SR, United Kingdom. ^[17] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.;Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington. ^[18] International Epidemiology Institute, 1455 Research Blvd, Suite 550, Rockville, Maryland. ^[19] Mayo Clinic, Rochester, Minnesota. ^[20] Department of Urology, University Hospital Ulm, Germany.;Institute of Human Genetics, University Hospital Ulm, Germany. ^[21] Brigham and Women's Hospital/Dana-Farber Cancer Institute, 45 Francis Street-ASB II-3, Boston, Massachussets.;Washington University, St Louis, Missouri. ^[22] International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. ^[23] Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah. ^[24] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[25] Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, Florida. ^[26] Molecular Medicine Center and Department of Medical Chemistry and Biochemistry, Medical University - Sofia, 2 Zdrave St, Sofia, 1431, Bulgaria. ^[27] Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia. ^[28] Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.;Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal. ^[29] The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom. ^[30] Commissariat à L'Energie Atomique, Center National De Génotypage, Evry, France.;McGill University-Génome Québec Innovation Centre, Montreal, Canada. ^[31] School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.;MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.;NIHR Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom. ^[32] NIHR Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom.;IGFs and Metabolic Endocrinology Group, School of Clinical Sciences North Bristol, University of Bristol, Bristol, United Kingdom. ^[33]

关键词 ALSPAC IGFBP3 Mendelian randomization PRACTICAL ProtecT UKHLS insulin-like growth factor-binding proteins insulin-like growth factors prostate cancer single nucleotide polymorphisms