首页> Journal of medicinal chemistry> Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

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第一作者： James F,Blake

第一单位： Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States.

作者： James F,Blake ^[1] ; Michael,Burkard ^[1] ; Jocelyn,Chan ^[2] ; Huifen,Chen ^[2] ; Kang-Jye,Chou ^[2] ; Dolores,Diaz ^[2] ; Danette A,Dudley ^[2] ; John J,Gaudino ^[1] ; Stephen E,Gould ^[2] ; Jonas,Grina ^[1] ; Thomas,Hunsaker ^[2] ; Lichuan,Liu ^[2] ; Matthew,Martinson ^[1] ; David,Moreno ^[1] ; Lars,Mueller ^[2] ; Christine,Orr ^[2] ; Patricia,Pacheco ^[2] ; Ann,Qin ^[2] ; Kevin,Rasor ^[1] ; Li,Ren ^[1] ; Kirk,Robarge ^[2] ; Sheerin,Shahidi-Latham ^[2] ; Jeffrey,Stults ^[2] ; Francis,Sullivan ^[1] ; Weiru,Wang ^[2] ; Jianping,Yin ^[2] ; Aihe,Zhou ^[2] ; Marcia,Belvin ^[2] ; Mark,Merchant ^[2] ; John,Moffat ^[2] ; Jacob B,Schwarz ^[2]

作者单位： Array BioPharma Inc. , 3200 Walnut Street, Boulder, Colorado 80301, United States. ^[1] Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. ^[2]