Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.

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作者： Gareth,Hall ^[1] ; Eilish,Cullen ^[2] ; Kovilen,Sawmynaden ^[2] ; Joanne,Arnold ^[2] ; Simon,Fox ^[2] ; Richard,Cowan ^[3] ; Frederick W,Muskett ^[3] ; David,Matthews ^[4] ; Andrew,Merritt ^[2] ; Catherine,Kettleborough ^[2] ; William,Cruikshank ^[5] ; Debra,Taylor ^[2] ; Richard,Bayliss ^[3] ; Mark D,Carr ^[6]

作者单位： From the Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, United Kingdom, gh126@le.ac.uk. ^[1] MRC Technology, Centre for Therapeutics Discovery, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, United Kingdom, and. ^[2] From the Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, United Kingdom. ^[3] MRC Technology, Centre for Therapeutics Discovery, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, United Kingdom, and david.matthews@tech.mrc.ac.uk. ^[4] the Boston University School of Medicine, Boston, Massachusetts 02118. ^[5] From the Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, United Kingdom, mdc12@le.ac.uk. ^[6]

关键词 cytokine interleukin interleukin-16 monoclonal antibody nuclear magnetic resonance (NMR)protein crystallization

主题词抗体, 单克隆(Antibodies, Monoclonal);结合部位, 抗体(Binding Sites, Antibody);结晶学, X线(Crystallography, X-Ray);人类(Humans);免疫球蛋白Fab片段(Immunoglobulin Fab Fragments);白细胞介素16(Interleukin-16);蛋白质结构, 二级(Protein Structure, Secondary)

DOI 10.1074/jbc.M115.709303

PMID 27231345

发布时间 2022-01-29

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