Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.

导出 LinkOut

翻译打印收藏纠错

第一作者： Yasemin Saygideger,Kont

第一单位： Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States; Department of Molecular Medicine, Institute of Health Sciences, Dokuz Eylul University, Inciralti, Izmir 35340, Turkey. Electronic address: ys452@georgetown.edu.

作者： Yasemin Saygideger,Kont ^[1] ; Arijit,Dutta ^[2] ; Apurva,Mallisetty ^[3] ; Jeena,Mathew ^[4] ; Tsion,Minas ^[5] ; Christina,Kraus ^[6] ; Priyanka,Dhopeshwarkar ^[7] ; Bhaskar,Kallakury ^[8] ; Sankar,Mitra ^[9] ; Aykut,Üren ^[10] ; Sanjay,Adhikari ^[11]

作者单位： Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States; Department of Molecular Medicine, Institute of Health Sciences, Dokuz Eylul University, Inciralti, Izmir 35340, Turkey. Electronic address: ys452@georgetown.edu. ^[1] Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX-77030, United States; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX-77555, United States. Electronic address: ardutta@utmb.edu. ^[2] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States. Electronic address: apurva.mallisetty@gmail.com. ^[3] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States. Electronic address: jm722@georgetown.edu. ^[4] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States. Electronic address: tm484@georgetown.edu. ^[5] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States. Electronic address: cnk10@georgetown.edu. ^[6] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States. Electronic address: priyanka.dhopeshwarkar@ablinc.com. ^[7] Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States. Electronic address: kallakub@georgetown.edu. ^[8] Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX-77030, United States. Electronic address: smitra2@houstonmethodist.org. ^[9] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States. Electronic address: au26@georgetown.edu. ^[10] Compass Laboratory Services, 1910 Nonconnah Rd, Memphis, United States. Electronic address: sadhikari@houstonmethodist.org. ^[11]

关键词 DNA repair Enzyme assay High throughput screening Inhibitor Molecular probe NSC111041 TDP2