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Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization.

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第一作者： Sheng,Wang

第一单位： Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.;Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.;Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

作者： Sheng,Wang ^[1] ; Peng,Huang ^[2] ; Xiaoyuan,Chen ^[3]

作者单位： Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.;Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.;Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA. ^[1] Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, P. R. China. peng.huang@szu.edu.cn. ^[2] Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA. shawn.chen@nih.gov. ^[3]

关键词 activatable surface ligands changeable particle sizes hierarchical targeting stimuli-responsive nanoplatforms switchable surface charges

医学主题词药物释放系统(Drug Delivery Systems);人类(Humans);纳米粒子(Nanoparticles);肿瘤(Neoplasms);粒子大小(Particle Size);肿瘤微环境(Tumor Microenvironment)

DOI 10.1002/adma.201601498

PMID 27255214

发布时间 2025-05-30

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