Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport.

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第一作者： Hong-Li,Guo

第一单位： Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China.

作者： Hong-Li,Guo ^[1] ; Hozeifa M,Hassan ^[2] ; Yun,Zhang ^[3] ; Si-Zhe,Dong ^[1] ; Ping-Ping,Ding ^[1] ; Tao,Wang ^[4] ; Li-Xin,Sun ^[4] ; Lu-Yong,Zhang ^[5] ; Zhen-Zhou,Jiang ^[6]

作者单位： Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China. ^[1] Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China Department of Pharmacology, Faculty of Pharmacy, University of Gezira, Wad-Medani, Sudan. ^[2] Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China Biology Institute of Shandong Academy of Sciences, Jinan 250014, China. ^[3] Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China. ^[4] Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, China; ^[5] Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China beaglejiang@cpu.edu.cn. ^[6]

关键词 bile acid cholestasis hepatotoxicity obeticholic acid.pyrazinamide