Properties and mechanisms of drug release from matrix tablets containing poly(ethylene oxide) and poly(acrylic acid) as release retardants.

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第一作者： Feng,Zhang

第一单位： Department of Pharmaceutics, The University of Texas at Austin, 2409 University Avenue, A1920, Austin, TX 78712, USA. Electronic address: feng.zhang@austin.utexas.edu.

作者： Feng,Zhang ^[1] ; Fan,Meng ^[2] ; Joseph,Lubach ^[3] ; Joseph,Koleng ^[2] ; N A,Watson ^[2]

作者单位： Department of Pharmaceutics, The University of Texas at Austin, 2409 University Avenue, A1920, Austin, TX 78712, USA. Electronic address: feng.zhang@austin.utexas.edu. ^[1] Department of Pharmaceutics, The University of Texas at Austin, 2409 University Avenue, A1920, Austin, TX 78712, USA. ^[2] Small Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94040, USA. ^[3]

关键词 Anomalous transport mechanism Fickian diffusion Interpolymer interaction Microenvironment pH Poly(acrylic acid)Poly(ethylene oxide)Sustained release

主题词丙烯酸树脂类(Acrylic Resins);缓冲剂(Buffers);氢离子浓度(Hydrogen-Ion Concentration);分子量(Molecular Weight);聚乙烯二醇类(Polyethylene Glycols);片剂(Tablets);茶碱(Theophylline)

DOI 10.1016/j.ejpb.2016.05.024

PMID 27260202

发布时间 2018-12-02

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