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首页> The Journal of biological chemistry> 14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun Protein.

14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun Protein.

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作者： Kumarkrishna,Raychaudhuri ^[1] ; Neelam,Chaudhary ^[2] ; Mansa,Gurjar ^[1] ; Roseline,D'Souza ^[1] ; Jazeel,Limzerwala ^[1] ; Subbareddy,Maddika ^[3] ; Sorab N,Dalal ^[4]

作者单位： From the KS215, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. ^[1] Laboratory of Cell Death and Cell Survival, Centre for DNA Fingerprinting and Diagnostics (CDFD), Nampally, Hyderabad 500001, India, and Graduate Studies, Manipal University, Manipal, Karnataka 576104, India. ^[2] Laboratory of Cell Death and Cell Survival, Centre for DNA Fingerprinting and Diagnostics (CDFD), Nampally, Hyderabad 500001, India, and. ^[3] From the KS215, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India, sdalal@actrec.gov.in. ^[4]

关键词 14–3-3 protein E3 ubiquitin ligase EMT transcription factors c-Jun transcription factor epithelial-mesenchymal transition (EMT)nuclear export tumor progression and metastasis tumor suppressor gene ubiquitin-mediated proteolysis

主题词 14-3-3蛋白质类(14-3-3 Proteins);主动转运, 细胞核(Active Transport, Cell Nucleus);细胞系(Cell Line);细胞核(Cell Nucleus);上皮-间质转化(Epithelial-Mesenchymal Transition);基因表达调控(Gene Expression Regulation);基因敲低技术(Gene Knockdown Techniques);人类(Humans);蛋白质稳定性(Protein Stability);原癌基因蛋白质c-jun(Proto-Oncogene Proteins c-jun);肿瘤抑制蛋白质类(Tumor Suppressor Proteins);泛素化(Ubiquitination)

DOI 10.1074/jbc.M116.723767

PMID 27261462

发布时间 2022-03-18

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The Journal of biological chemistry

The Journal of biological chemistry

2016年291卷31期

16068-81页

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