Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.
作者:
Tasha E,Fingerlin [1]
;
Weiming,Zhang [2]
;
Ivana V,Yang [3]
;
Hannah C,Ainsworth [4]
;
Pamela H,Russell [5]
;
Rachel Z,Blumhagen [6]
;
Marvin I,Schwarz [7]
;
Kevin K,Brown [3]
;
Mark P,Steele [4]
;
James E,Loyd [7]
;
Gregory P,Cosgrove [8]
;
David A,Lynch [8]
;
Steve,Groshong [7]
;
Harold R,Collard [7]
;
Paul J,Wolters [7]
;
Williamson Z,Bradford [9]
;
Karl,Kossen [9]
;
Scott D,Seiwert [10]
;
Roland M,du Bois [10]
;
Christine Kim,Garcia [10]
;
Megan S,Devine [11]
;
Gunnar,Gudmundsson [12]
;
Helgi J,Isaksson [13]
;
Naftali,Kaminski [13]
;
Yingze,Zhang [14]
;
Kevin F,Gibson [14]
;
Lisa H,Lancaster [15]
;
Toby M,Maher [15]
;
Philip L,Molyneaux [15]
;
Athol U,Wells [8]
;
Miriam F,Moffatt [11]
;
Moises,Selman [12]
;
Annie,Pardo [11]
;
Dong Soon,Kim [12]
;
James D,Crapo [11]
;
Barry J,Make [12]
;
Elizabeth A,Regan [11]
;
Dinesha S,Walek [12]
;
Jerry J,Daniel [16]
;
Yoichiro,Kamatani [17]
;
Diana,Zelenika [18]
;
Elissa,Murphy [7]
;
Keith,Smith [7]
;
David,McKean [7]
;
Brent S,Pedersen [19]
;
Janet,Talbert [19]
;
Julia,Powers [20]
;
Cheryl R,Markin [21]
;
Kenneth B,Beckman [4]
;
Mark,Lathrop [4]
;
Brian,Freed [4]
;
Carl D,Langefeld [4]
;
David A,Schwartz [4]
作者单位:
Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA. fingerlint@njhealth.org.
[1]
Department of Biostatistics and Informatics, University of Colorado Denver, Aurora, CO, USA. fingerlint@njhealth.org.
[2]
Department of Biostatistics and Informatics, University of Colorado Denver, Aurora, CO, USA.
[3]
Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, CO, USA.
[4]
Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[5]
Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, Aurora, CO, USA.
[6]
Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
[7]
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
[8]
Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
[9]
InterMune, Brisbane, CA, USA.
[10]
National Heart and Lung Institute, Imperial College, London, UK.
[11]
National Institute for Health Research Biomedical Research Unit, Royal Brompton Hospital, London, UK.
[12]
Department of Medicine, University of Texas Southwestern, Dallas, TX, USA.
[13]
Landspitali University Hospital and University of Iceland Faculty of Medicine, Reykjavik, Iceland.
[14]
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
[15]
Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
[16]
Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.
[17]
Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
[18]
University of Minnesota Genomics Center, University of Minnesota, Minneapolis, MN, USA.
[19]
Fondation Jean Dausset, Centre d'Étude du Polymorphisme Humain, Paris, France.
[20]
Commissariat à l'Energie Atomique, Institut Génomique, Centre National de Génotypage, Evry, France.
[21]
Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA. david.schwartz@ucdenver.edu.
[22]
Department of Medicine, School of Medicine, University of Colorado Denver, Aurora, CO, USA. david.schwartz@ucdenver.edu.
[23]
Department of Immunology, School of Medicine, University of Colorado Denver, Aurora, CO, USA. david.schwartz@ucdenver.edu.
[24]
主题词
成年人(Adult);老年人(Aged);染色体, 人, 6对(Chromosomes, Human, Pair 6);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);特发性肺纤维化(Idiopathic Pulmonary Fibrosis);连锁不平衡(Linkage Disequilibrium);男(雄)性(Male);中年人(Middle Aged);肺纤维化(Pulmonary Fibrosis);序列分析, RNA(Sequence Analysis, RNA)
DOI
10.1186/s12863-016-0377-2
PMID
27266705
发布时间
2023-07-22
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BMC genetics
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