Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.-论文-万方医学网

作者： Risa,Kashima ^[1] ; Sougata,Roy ^[1] ; Manuel,Ascano ^[2] ; Veronica,Martinez-Cerdeno ^[3] ; Jeanelle,Ariza-Torres ^[4] ; Sunghwan,Kim ^[1] ; Justin,Louie ^[1] ; Yao,Lu ^[1] ; Patricio,Leyton ^[5] ; Kenneth D,Bloch ^[5] ; Thomas B,Kornberg ^[1] ; Paul J,Hagerman ^[6] ; Randi,Hagerman ^[7] ; Giorgio,Lagna ^[1] ; Akiko,Hata ^[8]

作者单位： Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA. ^[1] Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA. ^[2] Institute for Pediatric Regenerative Medicine, Department of Pathology, University of California, Davis, Davis, CA 95817, USA. MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA 95817, USA. ^[3] Institute for Pediatric Regenerative Medicine, Department of Pathology, University of California, Davis, Davis, CA 95817, USA. ^[4] Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA. ^[5] Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA 95817, USA. ^[6] MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA 95817, USA. ^[7] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA. akiko.hata@ucsf.edu. ^[8]

主题词动物(Animals);孤独性障碍(Autistic Disorder);骨形态发生蛋白受体, Ⅱ型(Bone Morphogenetic Protein Receptors, Type II);脑(Brain);丝切蛋白1(Cofilin 1);交叉, 遗传(Crosses, Genetic);黑腹果蝇(Drosophila melanogaster);脆性X综合征(Fragile X Syndrome);基因表达调控(Gene Expression Regulation);HEK293细胞(HEK293 Cells);杂合子(Heterozygote);人类(Humans);Lim激酶类(Lim Kinases);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);神经突(Neurites);神经元(Neurons);磷酰化(Phosphorylation);质粒(Plasmids);额叶前皮质(Prefrontal Cortex);RNA, 小分子干扰(RNA, Small Interfering);信号传导(Signal Transduction)

DOI 10.1126/scisignal.aaf6060

PMID 27273096

发布时间 2018-11-13

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Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.

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Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.

Science signaling

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Science signaling

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