Discovery of potent macrocyclic HCV NS5A inhibitors.

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作者： Wensheng,Yu ^[1] ; Bancha,Vibulbhan ^[2] ; Stuart B,Rosenblum ^[2] ; Gregory S,Martin ^[3] ; A Samuel,Vellekoop ^[3] ; Christian L,Holst ^[3] ; Craig A,Coburn ^[4] ; Michael,Wong ^[2] ; Oleg,Selyutin ^[2] ; Tao,Ji ^[5] ; Bin,Zhong ^[5] ; Bin,Hu ^[5] ; Lei,Chen ^[2] ; Michael P,Dwyer ^[2] ; Yueheng,Jiang ^[2] ; Anilkumar G,Nair ^[2] ; Ling,Tong ^[2] ; Qingbei,Zeng ^[2] ; Sony,Agrawal ^[6] ; Donna,Carr ^[6] ; Laura,Rokosz ^[6] ; Rong,Liu ^[7] ; Stephanie,Curry ^[7] ; Patricia,McMonagle ^[7] ; Paul,Ingravallo ^[7] ; Fred,Lahser ^[7] ; Ernest,Asante-Appiah ^[7] ; James,Fells ^[8] ; Joseph A,Kozlowski ^[2]

作者单位： Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: wensheng.yu@merck.com. ^[1] Department of Medicinal Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA. ^[2] Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA. ^[3] Department of Medicinal Chemistry, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA. ^[4] WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China. ^[5] Department of In Vitro Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ^[6] Department of Infectious Diseases, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ^[7] Department of Structural Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065 USA. ^[8]

关键词 DAA HCV NS5A inhibitor HCV infection MK-4882 MK-8325 Macrocycle