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首页> The Journal of pharmacy and pharmacology> Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine.

Hot melt extrusion as an approach to improve solubility, permeability and oral absorption of a psychoactive natural product, piperine.

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作者： Eman A,Ashour ^[1] ; Soumyajit,Majumdar ^[1] ; Abdulla,Alsheteli ^[2] ; Sultan,Alshehri ^[3] ; Bader,Alsulays ^[4] ; Xin,Feng ^[3] ; Andreas,Gryczke ^[1] ; Karl,Kolter ^[5] ; Nigel,Langley ^[6] ; Michael A,Repka ^[7]

作者单位： Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA. ^[1] Pii Center for Pharmaceutical Technology, The University of Mississippi, University, MS, 38677, USA. ^[2] Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia. ^[3] Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. ^[4] Global Development and Technical Marketing, BASF SE, Ludwigshafen, 67056, Germany. ^[5] R&D Product Management Excipients, BASF SE, Ludwigshafen, 67056, Germany. ^[6] BASF Corporation, 500 White Plains Road, Tarrytown, NY, USA. ^[7]

关键词 hot melt extrusion permeability piperine solubility

主题词生物碱类(Alkaloids);动物(Animals);苯并二恶茂类(Benzodioxoles);生物利用度(Biological Availability);药物调剂(Drug Compounding);热温度(Hot Temperature);男(雄)性(Male);通透性(Permeability);哌啶类(Piperidines);植物提取物(Plant Extracts);聚乙烯二醇类(Polyethylene Glycols);聚甲基丙烯酸类(Polymethacrylic Acids);多不饱和脂肪酸酰胺类(Polyunsaturated Alkamides);乙烯类聚合物(Polyvinyls);聚维酮(Povidone);精神治疗药物(Psychotropic Drugs);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);溶解度(Solubility);水(Water)

DOI 10.1111/jphp.12579

PMID 27283755

发布时间 2020-03-06

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The Journal of pharmacy and pharmacology

The Journal of pharmacy and pharmacology

2016年68卷8期

989-98页

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