Pre-absorption physicochemical compatibility assessment of 8-drug metabolic cocktail.

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作者： Ching Kim,Tye ^[1] ; Zhanbin,Wang ^[2] ; Randy C,Dockens ^[3] ; Blisse,Vakkalagadda ^[3] ; Chunlei,Wang ^[4] ; Yingru,Zhang ^[4] ; Ching Chiang,Su ^[2] ; Michael J,Hageman ^[2]

作者单位： Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, NJ, USA. Electronic address: chingkim@gmail.com. ^[1] Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, NJ, USA. ^[2] Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Princeton, NJ, USA. ^[3] Bioanalytical and Discovery Analytical Sciences, Bristol-Myers Squibb, Princeton, NJ, USA. ^[4]

关键词 Caffeine (PubChem CID: 2519)Co-administration Digoxin (PubChem CID: 2724385)Flurbiprofen (PubChem CID: 3394)Metabolic cocktail Metoprolol (PubChem CID: 11957594)Midazolam (PubChem CID: 4192)Montelukast (PubChem CID: 5281040)Omeprazole (PubChem CID: 4594)Physicochemical interaction Pravastatin (PubChem CID: 16759173)

主题词化学现象(Chemical Phenomena);复方合剂(Drug Combinations);药物调剂(Drug Compounding);药物相互作用(Drug Interactions);氢离子浓度(Hydrogen-Ion Concentration)

DOI 10.1016/j.ijpharm.2016.06.028

PMID 27291974

发布时间 2017-05-17

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