Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.
作者:
Eloy F,Robles [1]
;
Maria,Mena-Varas [1]
;
Laura,Barrio [2]
;
Sara V,Merino-Cortes [2]
;
Péter,Balogh [3]
;
Ming-Qing,Du [4]
;
Takashi,Akasaka [5]
;
Anton,Parker [6]
;
Sergio,Roa [1]
;
Carlos,Panizo [7]
;
Idoia,Martin-Guerrero [8]
;
Reiner,Siebert [8]
;
Victor,Segura [9]
;
Xabier,Agirre [1]
;
Laura,Macri-Pellizeri [1]
;
Beatriz,Aldaz [1]
;
Amaia,Vilas-Zornoza [1]
;
Shaowei,Zhang [4]
;
Sarah,Moody [4]
;
Maria Jose,Calasanz [10]
;
Thomas,Tousseyn [11]
;
Cyril,Broccardo [12]
;
Pierre,Brousset [12]
;
Elena,Campos-Sanchez [13]
;
Cesar,Cobaleda [13]
;
Isidro,Sanchez-Garcia [14]
;
Jose Luis,Fernandez-Luna [15]
;
Ricardo,Garcia-Muñoz [16]
;
Esther,Pena [17]
;
Beatriz,Bellosillo [18]
;
Antonio,Salar [19]
;
Maria Joao,Baptista [20]
;
Jesús Maria,Hernandez-Rivas [21]
;
Marcos,Gonzalez [21]
;
Maria Jose,Terol [22]
;
Joan,Climent [22]
;
Antonio,Ferrandez [23]
;
Xavier,Sagaert [11]
;
Ari M,Melnick [24]
;
Felipe,Prosper [1]
;
David G,Oscier [7]
;
Yolanda R,Carrasco [6]
;
Martin J S,Dyer [2]
;
Jose A,Martinez-Climent [5]
作者单位:
Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain.
[1]
Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid 28049, Spain.
[2]
Department of Immunology and Biotechnology, Szentágothai Research Center, University of Pécs, Pécs H-7624, Hungary.
[3]
Division of Molecular Histopathology, Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK.
[4]
MRC Toxicology Unit and Ernest and Helen Scott Haematological Research Institute, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK.
[5]
Department of Haematology, Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK.
[6]
Department of Hematology, Clinica Universidad de Navarra, IDISNA, Pamplona 31008, Spain.
[7]
Institute of Human Genetics, Christian-Albrechts-University Kiel &University Hospital Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
[8]
Bio-informatic Unit, Department of Genomics and Proteomics, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain.
[9]
Department of Genetics, School of Medicine, University of Navarra, IDISNA, Pamplona 31008, Spain.
[10]
Centre for Translation Cell and Tissue Research, KU Leuven, Leuven 3000, Belgium.
[11]
Department of Pathology, Institut Universitaire du Cancer de Toulouse-Oncopole, Labex TOUCAN and CRCT INSERM U1037, Toulouse F-31053, France.
[12]
Centro de Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma, Madrid 28049, Spain.
[13]
Experimental Therapeutics and Translational Oncology Program, Institute of Molecular and Cellular Biology of Cancer, CSIC/University of Salamanca; and Institute of Biomedical Research of Salamanca (IBSAL), Salamanca 37007, Spain.
[14]
Molecular Genetics Unit, University Hospital Marques de Valdecilla and IFIMAV, Santander 39011, Spain.
[15]
Hematology Department, Hospital San Pedro, Logroño, 26006, La Rioja, Spain.
[16]
Department of Hematology, Complejo Hospitalario de Navarra, Servicio Navarro de Salud, IDISNA, Pamplona 31008, Spain.
[17]
Department of Pathology, Cancer Research Program, Institut Municipal d'Investigacions Mèdiques (IMIM), Hospital del Mar, Barcelona 08003, Spain.
[18]
Department of Clinical Hematology, Cancer Research Program, Institut Municipal d'Investigacions Mèdiques (IMIM), Hospital del Mar, Barcelona 08003, Spain.
[19]
Department of Hematology, ICO-Hospital Universitari Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Universitat Autònoma de Barcelona, Badalona 08916, Spain.
[20]
Department of Hematology, IBSAL-University Hospital and IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain.
[21]
Department of Hematology, Hospital Clinico, INCLIVA Biomedical Research Institute, University of Valencia, Valencia 46010, Spain.
[22]
Department of Pathology, Hospital Clinico, University of Valencia, Valencia 46010, Spain.
[23]
Department of Medicine/Hematology-Oncology, Weill Cornell Medical College, New York, New York 10065, USA.
[24]
主题词
动物(Animals);细胞黏附分子(Cell Adhesion Molecules);基因表达谱(Gene Expression Profiling);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);Kaplan-Meiers评估(Kaplan-Meier Estimate);淋巴细胞(Lymphocytes);淋巴组织(Lymphoid Tissue);淋巴瘤, B细胞, 边缘区(Lymphoma, B-Cell, Marginal Zone);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);磷酰化(Phosphorylation);受体, 抗原, B细胞(Receptors, Antigen, B-Cell);信号传导(Signal Transduction);转录因子(Transcription Factors)
DOI
10.1038/ncomms11889
PMID
27297662
发布时间
2022-01-29
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Nature communications
11889页
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