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Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.

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作者单位: Division of Hemato-Oncology, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain. [1] Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid 28049, Spain. [2] Department of Immunology and Biotechnology, Szentágothai Research Center, University of Pécs, Pécs H-7624, Hungary. [3] Division of Molecular Histopathology, Department of Pathology, Cambridge University, Cambridge CB2 1QP, UK. [4] MRC Toxicology Unit and Ernest and Helen Scott Haematological Research Institute, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK. [5] Department of Haematology, Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK. [6] Department of Hematology, Clinica Universidad de Navarra, IDISNA, Pamplona 31008, Spain. [7] Institute of Human Genetics, Christian-Albrechts-University Kiel &University Hospital Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany. [8] Bio-informatic Unit, Department of Genomics and Proteomics, Center for Applied Medical Research CIMA, University of Navarra, IDISNA, Pamplona 31008, Spain. [9] Department of Genetics, School of Medicine, University of Navarra, IDISNA, Pamplona 31008, Spain. [10] Centre for Translation Cell and Tissue Research, KU Leuven, Leuven 3000, Belgium. [11] Department of Pathology, Institut Universitaire du Cancer de Toulouse-Oncopole, Labex TOUCAN and CRCT INSERM U1037, Toulouse F-31053, France. [12] Centro de Biologia Molecular Severo Ochoa, CSIC/Universidad Autonoma, Madrid 28049, Spain. [13] Experimental Therapeutics and Translational Oncology Program, Institute of Molecular and Cellular Biology of Cancer, CSIC/University of Salamanca; and Institute of Biomedical Research of Salamanca (IBSAL), Salamanca 37007, Spain. [14] Molecular Genetics Unit, University Hospital Marques de Valdecilla and IFIMAV, Santander 39011, Spain. [15] Hematology Department, Hospital San Pedro, Logroño, 26006, La Rioja, Spain. [16] Department of Hematology, Complejo Hospitalario de Navarra, Servicio Navarro de Salud, IDISNA, Pamplona 31008, Spain. [17] Department of Pathology, Cancer Research Program, Institut Municipal d'Investigacions Mèdiques (IMIM), Hospital del Mar, Barcelona 08003, Spain. [18] Department of Clinical Hematology, Cancer Research Program, Institut Municipal d'Investigacions Mèdiques (IMIM), Hospital del Mar, Barcelona 08003, Spain. [19] Department of Hematology, ICO-Hospital Universitari Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Universitat Autònoma de Barcelona, Badalona 08916, Spain. [20] Department of Hematology, IBSAL-University Hospital and IBMCC-CSIC, University of Salamanca, Salamanca 37007, Spain. [21] Department of Hematology, Hospital Clinico, INCLIVA Biomedical Research Institute, University of Valencia, Valencia 46010, Spain. [22] Department of Pathology, Hospital Clinico, University of Valencia, Valencia 46010, Spain. [23] Department of Medicine/Hematology-Oncology, Weill Cornell Medical College, New York, New York 10065, USA. [24]
DOI 10.1038/ncomms11889
PMID 27297662
发布时间 2022-01-29
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