Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.

导出 OA

翻译打印收藏纠错

作者： Yaling,Yin ^[1] ; Di,Gao ^[1] ; Yali,Wang ^[1] ; Zhi-Hao,Wang ^[1] ; Xin,Wang ^[1] ; Jinwang,Ye ^[1] ; Dongqin,Wu ^[1] ; Lin,Fang ^[1] ; Guilin,Pi ^[1] ; Ying,Yang ^[1] ; Xiao-Chuan,Wang ^[1] ; Chengbiao,Lu ^[2] ; Keqiang,Ye ^[3] ; Jian-Zhi,Wang ^[4]

作者单位： Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; ^[1] Department of Physiology and Neurobiology, Henan Province Key Laboratory of Brain Research, Xinxiang Medical University, Xinxiang 453003, China; ^[2] Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322; ^[3] Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong JS 226001, China wangjz@mails.tjmu.edu.cn. ^[4]

关键词 Alzheimer’s disease CREB Ca2+/calmodulin-dependent kinase IV calcineurin tau