Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against Aβ25-35-induced neuronal damage.

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第一作者： Jing,Chen

第一单位： State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.

作者： Jing,Chen ^[1] ; Ling-Xue,Tao ^[2] ; Wei,Xiao ^[3] ; Sha-Sha,Ji ^[4] ; Jian-Rong,Wang ^[1] ; Xu-Wen,Li ^[5] ; Hai-Yan,Zhang ^[6] ; Yue-Wei,Guo ^[7]

作者单位： State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China. ^[1] CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR China. ^[2] Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang 222001, PR China. ^[3] School of Biological Science and Technology, Weifang Medical University, 7166 Bao Tong West Street, Weifang, Shandong 261053, PR China. ^[4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China. Electronic address: xwli@simm.ac.cn. ^[5] CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR China. Electronic address: hzhang@simm.ac.cn. ^[6] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China. Electronic address: ywguo@simm.ac.cn. ^[7]

关键词 Alzheimer’s disease Neuroprotective agent Oxa-Pictet–Spengler reaction Oxazino-indoles SAR