Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.-论文-万方医学网

第一作者： Rama Subba Rao,Vidadala

第一单位： Department of Chemistry, University of Washington , Seattle, Washington 98195, United States.

作者： Rama Subba Rao,Vidadala ^[1] ; Kasey L,Rivas ^[2] ; Kayode K,Ojo ^[2] ; Matthew A,Hulverson ^[2] ; Jennifer A,Zambriski ^[3] ; Igor,Bruzual ^[4] ; Tracey L,Schultz ^[5] ; Wenlin,Huang ^[6] ; Zhongsheng,Zhang ^[6] ; Suzanne,Scheele ^[7] ; Amy E,DeRocher ^[7] ; Ryan,Choi ^[2] ; Lynn K,Barrett ^[2] ; Latha Kallur,Siddaramaiah ^[6] ; Wim G J,Hol ^[6] ; Erkang,Fan ^[6] ; Ethan A,Merritt ^[6] ; Marilyn,Parsons ^[8] ; Gail,Freiberg ^[9] ; Kennan,Marsh ^[9] ; Dale J,Kempf ^[9] ; Vern B,Carruthers ^[5] ; Nina,Isoherranen ^[10] ; J Stone,Doggett ^[4] ; Wesley C,Van Voorhis ^[11] ; Dustin J,Maly ^[12]

作者单位： Department of Chemistry, University of Washington , Seattle, Washington 98195, United States. ^[1] Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States. ^[2] Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University , Pullman, Washington 99164, United States. ^[3] Portland VA Medical Center , Portland, Oregon 97239, United States. ^[4] Department of Microbiology and Immunology, University of Michigan Medical School , Ann Arbor, Michigan 48109, United States. ^[5] Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States. ^[6] Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States. ^[7] Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States.;Department of Global Health, University of Washington , Seattle, Washington 98195, United States. ^[8] AbbVie , North Chicago, Illinois 60064, United States. ^[9] Department of Pharmaceutics, University of Washington , Seattle, Washington 98195, United States. ^[10] Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-Emerging Infectious Diseases (CERID), University of Washington , Seattle, Washington 98109, United States.;Department of Global Health, University of Washington , Seattle, Washington 98195, United States. ^[11] Department of Biochemistry, University of Washington , Seattle, Washington 98195, United States.;Department of Chemistry, University of Washington , Seattle, Washington 98195, United States. ^[12]

医学主题词投药, 口服(Administration, Oral);动物(Animals);抗原虫药(Antiprotozoal Agents);中枢神经系统(Central Nervous System);疾病模型, 动物(Disease Models, Animal);狗(Dogs);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);快速延迟整流钾通道(Ether-A-Go-Go Potassium Channels);女(雌)性(Female);直鼻猴亚目(Haplorhini);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);分子结构(Molecular Structure);寄生虫敏感性试验(Parasitic Sensitivity Tests);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白激酶类(Protein Kinases);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);构效关系(Structure-Activity Relationship);弓形虫属(Toxoplasma);弓形虫病(Toxoplasmosis)

DOI 10.1021/acs.jmedchem.6b00760

PMID 27309760

发布时间 2018-11-13

检索历史清除

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Journal of medicinal chemistry

相似文献

同项目论文

Journal of medicinal chemistry

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Journal of medicinal chemistry

相似文献

同项目论文

Journal of medicinal chemistry

相关期刊

检索历史清除