The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.

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作者： Abigail D G,Nunn ^[1] ; Tullio,Scopigno ^[2] ; Natalia,Pediconi ^[1] ; Massimo,Levrero ^[2] ; Henning,Hagman ^[3] ; Juris,Kiskis ^[1] ; Annika,Enejder ^[4]

作者单位： Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy. ^[1] Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. ^[2] Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291-293, 00161 Rome, Italy. ^[3] Department of Internal Medicine, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. ^[4] INSERM U1052- Cancer Research Center of Lyon (CRCL), 151 Cours Albert Thomas, 69008 Lyon, France. ^[5] Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon 69004, France. ^[6] Department of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden. ^[7]

主题词苯甲酰胺类(Benzamides);细胞分化(Cell Differentiation);细胞系(Cell Line);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);组蛋白脱乙酰基酶类(Histone Deacetylases);人类(Humans);图像处理, 计算机辅助(Image Processing, Computer-Assisted);油酸(Oleic Acid);吡啶类(Pyridines);硬脂酰CoA去饱和酶(Stearoyl-CoA Desaturase);甘油三酯类(Triglycerides);增量调节(Up-Regulation)

DOI 10.1038/srep28025

PMID 27320682

发布时间 2018-11-13

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The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.

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The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.

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