Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.

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作者： Svein Isungset,Støve ^[1] ; Robert S,Magin ^[2] ; Håvard,Foyn ^[3] ; Bengt Erik,Haug ^[4] ; Ronen,Marmorstein ^[5] ; Thomas,Arnesen ^[6]

作者单位： Department of Molecular Biology, University of Bergen, 5020 Bergen, Norway; Department of Surgery, Haukeland University Hospital, 5021 Bergen, Norway. ^[1] Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Program in Gene Expression and Regulation, Wistar Institute, Philadelphia, PA 19104, USA. ^[2] Department of Molecular Biology, University of Bergen, 5020 Bergen, Norway. ^[3] Department of Chemistry, University of Bergen, 5020 Bergen, Norway. ^[4] Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Program in Gene Expression and Regulation, Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: marmor@mail.med.upenn.edu. ^[5] Department of Molecular Biology, University of Bergen, 5020 Bergen, Norway; Department of Surgery, Haukeland University Hospital, 5021 Bergen, Norway. Electronic address: thomas.arnesen@uib.no. ^[6]

关键词 N-terminal acetylation NAT Naa60 NatF acetyltransferase crystal structure

主题词催化域(Catalytic Domain);结晶学, X线(Crystallography, X-Ray);酶稳定性(Enzyme Stability);高尔基体(Golgi Apparatus);人类(Humans);细胞内膜(Intracellular Membranes);蛋白质结合(Protein Binding)

DOI 10.1016/j.str.2016.04.020

PMID 27320834

发布时间 2019-12-10

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