PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.

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作者： Robert S,Banh ^[1] ; Caterina,Iorio ^[2] ; Richard,Marcotte ^[2] ; Yang,Xu ^[2] ; Dan,Cojocari ^[1] ; Anas Abdel,Rahman ^[2] ; Judy,Pawling ^[1] ; Wei,Zhang ^[2] ; Ankit,Sinha ^[3] ; Christopher M,Rose ^[4] ; Marta,Isasa ^[3] ; Shuang,Zhang ^[5] ; Ronald,Wu ^[1] ; Carl,Virtanen ^[2] ; Toshiaki,Hitomi ^[6] ; Toshiyuki,Habu ^[6] ; Sachdev S,Sidhu ^[7] ; Akio,Koizumi ^[1] ; Sarah E,Wilkins ^[2] ; Thomas,Kislinger ^[2] ; Steven P,Gygi ^[8] ; Christopher J,Schofield ^[9] ; James W,Dennis ^[5] ; Bradly G,Wouters ^[8] ; Benjamin G,Neel ^[10]

作者单位： Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada. ^[1] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada. ^[2] Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada. ^[3] Department of Genetics, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. ^[4] Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. ^[5] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. ^[6] Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York University, New York, NY 10016, USA. ^[7] Department of Health and Environmental Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. ^[8] Department of Radiation System Biology, Institute of Radiation Biology Center, Kyoto University, Kyoto, Japan. ^[9] Chemistry Research Laboratory, Oxford University, 12 Mansfield Road, Oxford OX1 3TA, UK. ^[10]