Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

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第一作者： Dolores,Del Prete

第一单位： From the Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461 and.

作者： Dolores,Del Prete ^[1] ; Richard C,Rice ^[2] ; Anjali M,Rajadhyaksha ^[3] ; Luciano,D'Adamio ^[4]

作者单位： From the Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461 and. ^[1] the Division of Pediatric Neurology, Department of Pediatrics, and. ^[2] the Division of Pediatric Neurology, Department of Pediatrics, and Feil Family Brain and Mind Research Institute, Weill Cornell Autism Research Program, Weill Cornell Medical College, New York, New York 10065. ^[3] From the Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461 and luciano.dadamio@einstein.yu.edu. ^[4]

关键词 Alzheimer disease CRL4CRBN Cereblon E3 ubiquitin ligase Intellectual disability amyloid precursor protein (APP)neurodegenerative disease ubiquitylation (ubiquitination)