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Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

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第一作者： Yan,Shi

第一单位： Research and Development, Bristol-Myers Squibb Company , 350 Carter Road, Hopewell, New Jersey 08540, United States.

作者： Yan,Shi ^[1] ; Jun,Li ^[1] ; Lawrence J,Kennedy ^[1] ; Shiwei,Tao ^[1] ; Andrés S,Hernández ^[1] ; Zhi,Lai ^[1] ; Sean,Chen ^[1] ; Henry,Wong ^[1] ; Juliang,Zhu ^[1] ; Ashok,Trehan ^[1] ; Ngiap-Kie,Lim ^[1] ; Huiping,Zhang ^[1] ; Bang-Chi,Chen ^[1] ; Kenneth T,Locke ^[1] ; Kevin M,O'Malley ^[1] ; Litao,Zhang ^[1] ; Rai Ajit,Srivastava ^[1] ; Bowman,Miao ^[1] ; Daniel S,Meyers ^[1] ; Hossain,Monshizadegan ^[1] ; Debra,Search ^[1] ; Denise,Grimm ^[1] ; Rongan,Zhang ^[1] ; Thomas,Harrity ^[1] ; Lori K,Kunselman ^[1] ; Michael,Cap ^[1] ; Jodi,Muckelbauer ^[1] ; Chiehying,Chang ^[1] ; Stanley R,Krystek ^[1] ; Yi-Xin,Li ^[1] ; Vinayak,Hosagrahara ^[1] ; Lisa,Zhang ^[1] ; Pathanjali,Kadiyala ^[1] ; Carrie,Xu ^[1] ; Michael A,Blanar ^[1] ; Robert,Zahler ^[1] ; Ranjan,Mukherjee ^[1] ; Peter T W,Cheng ^[1] ; Joseph A,Tino ^[1]

作者单位： Research and Development, Bristol-Myers Squibb Company , 350 Carter Road, Hopewell, New Jersey 08540, United States. ^[1]

关键词 Peroxisome proliferator-activated receptor (PPAR) α selective agonist high fat fed hamster model human ApoA1 transgenic mice pharmacokinetics

DOI 10.1021/acsmedchemlett.6b00033

PMID 27326332

发布时间 2020-10-01

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