换一批Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.
第一作者：
Bram P,Prins
第一单位：
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
作者：
Bram P,Prins [1]
;
Ali,Abbasi [2]
;
Anson,Wong [3]
;
Ahmad,Vaez [4]
;
Ilja,Nolte [5]
;
Nora,Franceschini [6]
;
Philip E,Stuart [7]
;
Javier,Guterriez Achury [8]
;
Vanisha,Mistry [9]
;
Jonathan P,Bradfield [10]
;
Ana M,Valdes [11]
;
Jose,Bras [12]
;
Aleksey,Shatunov [13]
;
PAGE Consortium [14]
;
International Stroke Genetics Consortium [15]
;
Systemic Sclerosis consortium [16]
;
Treat OA consortium [17]
;
DIAGRAM Consortium [18]
;
CARDIoGRAMplusC4D Consortium [19]
;
ALS consortium [20]
;
International Parkinson’s Disease Genomics Consortium [7]
;
Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium [21]
;
CKDGen consortium [22]
;
GERAD1 Consortium [23]
;
International Consortium for Blood Pressure [24]
;
Schizophrenia Working Group of the Psychiatric Genomics Consortium [25]
;
Inflammation Working Group of the CHARGE Consortium [26]
;
Chen,Lu [27]
;
Buhm,Han [28]
;
Soumya,Raychaudhuri [21]
;
Steve,Bevan [17]
;
Maureen D,Mayes [7]
;
Lam C,Tsoi [29]
;
Evangelos,Evangelou [30]
;
Rajan P,Nair [31]
;
Struan F A,Grant [32]
;
Constantin,Polychronakos [28]
;
Timothy R D,Radstake [33]
;
David A,van Heel [34]
;
Melanie L,Dunstan [35]
;
Nicholas W,Wood [8]
;
Ammar,Al-Chalabi [36]
;
Abbas,Dehghan [37]
;
Hakon,Hakonarson [38]
;
Hugh S,Markus [39]
;
James T,Elder [5]
;
Jo,Knight [40]
;
Dan E,Arking ;
Timothy D,Spector ;
Bobby P C,Koeleman ;
Cornelia M,van Duijn ;
Javier,Martin ;
Andrew P,Morris ;
Rinse K,Weersma ;
Cisca,Wijmenga ;
Patricia B,Munroe ;
John R B,Perry ;
Jennie G,Pouget ;
Yalda,Jamshidi ;
Harold,Snieder ;
Behrooz Z,Alizadeh
作者单位：
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
[1]
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.;Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
[2]
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.;Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
[3]
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
[4]
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
[5]
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
[6]
Department of Dermatology, Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, United States of America.
[7]
Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
[8]
Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.;Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
[9]
Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, United States of America.
[10]
Department of Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom.
[11]
Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom.
[12]
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
[13]
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
[14]
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
[15]
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.;Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.;Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.;Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America.;Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.
[16]
Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
[17]
Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
[18]
Department of Dermatology, Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, United States of America.;Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
[19]
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.;Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
[20]
Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, United States of America.;Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America.
[21]
Endocrine Genetics Research Institute, McGill University Health Center, Montreal, Quebec, Canada.
[22]
Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
[23]
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
[24]
Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
[25]
Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.
[26]
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.;Complex Disease Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.
[27]
Department of Epidemiology, Erasmus University Rotterdam, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
[28]
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.;Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.;Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.;Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
[29]
McKusick-Nathans Institute of Genetic Medicine and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
[30]
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
[31]
Complex Genetic Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
[32]
Instituto de Parasitologia y Biomedicina Lopez-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain.
[33]
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.
[34]
Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
[35]
NIHR Barts Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.;Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom.
[36]
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
[37]
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.;Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.;Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
[38]
Cardiogenetics Lab, Cardiovascular and Cell Sciences Institute, St George's Hospital Medical School, London, United Kingdom.
[39]
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
[40]
医学主题词
C反应蛋白质(C-Reactive Protein);全基因组关联研究(Genome-Wide Association Study);基因型(Genotype);心脏病(Heart Diseases);人类(Humans);免疫系统疾病(Immune System Diseases);孟德尔随机化分析(Mendelian Randomization Analysis);精神障碍(Mental Disorders);代谢疾病(Metabolic Diseases);多态性, 单核苷酸(Polymorphism, Single Nucleotide)
DOI
10.1371/journal.pmed.1001976
PMID
27327646
发布时间
2025-06-14
- 浏览33
PLoS medicine
PLoS medicine
e1001976页
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