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Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome.

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第一作者： Hélène,Darville

第一单位： CECS, I-STEM, AFM, 91030 Evry Cedex, France.

作者： Hélène,Darville ^[1] ; Aurélie,Poulet ^[1] ; Frédérique,Rodet-Amsellem ^[2] ; Laure,Chatrousse ^[1] ; Julie,Pernelle ^[3] ; Claire,Boissart ^[1] ; Delphine,Héron ^[4] ; Caroline,Nava ^[4] ; Anselme,Perrier ^[3] ; Margot,Jarrige ^[3] ; Francis,Cogé ^[5] ; Mark J,Millan ^[5] ; Thomas,Bourgeron ^[6] ; Marc,Peschanski ^[3] ; Richard,Delorme ^[7] ; Alexandra,Benchoua ^[8]

作者单位： CECS, I-STEM, AFM, 91030 Evry Cedex, France. ^[1] Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Department of Child and Adolescent Psychiatry, Paris, France. ^[2] INSERM UMR 861 I-STEM AFM, 91030 Evry Cedex, France; UEVE UMR 861 I-STEM AFM, 91030 Evry Cedex, France. ^[3] Assistance Publique-Hôpitaux de Paris, Department of Genetic and Cytogenetic, Pitié-Salpêtrière Hospital, 75013 Paris, France; Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, F-75013 Paris, France. ^[4] IDR Servier, Croissy sur Seine, France. ^[5] Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France; CNRS UMR 3571: Genes, synapses and cognition, Institut Pasteur, Paris, France; University Denis Diderot, Sorbonne Paris Cité, Paris, France. ^[6] Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Department of Child and Adolescent Psychiatry, Paris, France; Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France. ^[7] CECS, I-STEM, AFM, 91030 Evry Cedex, France. Electronic address: abenchoua@istem.fr. ^[8]

关键词 Autism Drug repurposing High throughput screening Lithium SHANK3 Valproate

医学主题词细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);单倍剂量不足(Haploinsufficiency);人类(Humans);锂(Lithium);男(雄)性(Male);神经组织蛋白质类(Nerve Tissue Proteins);神经元可塑性(Neuronal Plasticity);神经元(Neurons);表型(Phenotype);多潜能干细胞(Pluripotent Stem Cells);RNA, 信使(RNA, Messenger);疾病严重程度指数(Severity of Illness Index);丙戊酸(Valproic Acid)

DOI 10.1016/j.ebiom.2016.05.032

PMID 27333044

发布时间 2018-11-13

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Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome.

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Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome.

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