Small molecule non-peptide inhibitors of botulinum neurotoxin serotype E: Structure-activity relationship and a pharmacophore model.

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作者： Gyanendra,Kumar ^[1] ; Rakhi,Agarwal ^[1] ; Subramanyam,Swaminathan ^[2]

作者单位： Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. ^[1] Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Electronic address: swami@bnl.gov. ^[2]

关键词 Botulinum neurotoxin Fluorene Inhibitor Pharmacophore Structure–activity relationship

主题词抗菌药(Anti-Bacterial Agents);肉毒毒素类(Botulinum Toxins);肉毒中毒(Botulism);螯合剂(Chelating Agents);肉毒梭状杆菌(Clostridium botulinum);芴类(Fluorenes);人类(Humans);多肽模拟物(Peptidomimetics);构效关系(Structure-Activity Relationship);突触体相关蛋白质25(Synaptosomal-Associated Protein 25)

DOI 10.1016/j.bmc.2016.06.036

PMID 27353886

发布时间 2017-12-07

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Bioorganic & medicinal chemistry

2016年24卷18期

3978-3985页

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Small molecule non-peptide inhibitors of botulinum neurotoxin serotype E: Structure-activity relationship and a pharmacophore model.

Bioorganic & medicinal chemistry

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Bioorganic & medicinal chemistry

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Small molecule non-peptide inhibitors of botulinum neurotoxin serotype E: Structure-activity relationship and a pharmacophore model.

Bioorganic & medicinal chemistry

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Bioorganic & medicinal chemistry

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